The 22-year-old has been sidelined with an ankle injury of late, but will return to first-team training at Melwood on Tuesday, according to the Liverpool Echo.
The Germany international made his first start of the campaign against Burton in the League Cup second round, but limped off with the aforementioned ankle problem midway through the second-half. He has not played since.
It would be a risk for Klopp to alter things for such an important game, but Can’s qualities have become increasingly evident since he joined from Bayer Leverkusen for £9.75million in July 2014.
When fully fit, his place in the starting line-up is not in doubt, but depending on how he fares in training this week, a cameo off the substitutes’ bench could make more sense against Antonio Conte’s side.
Dejan Lovren will also be monitored in the coming days, after the Croatian missed the win over Leicester with a severe black eye.
Lucas Leiva played well in Lovren’s absence, despite his catastrophic error that led to Jamie Vardy’s goal, but Klopp will surely be keen to get his first-choice centre-back pairing of Lovren and Joel Matip back on the pitch.