Having suffered a hammer blow of back-to-back defeats to Swansea City in the Premier League and Southampton in the semi-finals of the League Cup, Klopp is in need of a statement performance on Saturday.
Though taking on a Wolves side as alarmingly inconsistent as themselves as they continue their pursuit of FA Cup glory, Liverpool will still need produce a strong display to seal the win at Anfield.
After naming the club’s youngest-ever starting lineup in the previous round against Plymouth Argyle, Klopp has opted for a safer approach this time around.
Loris Karius, who was so impressive in both legs against the Saints, keeps his place between the sticks, with Klopp opting to rotate his goalkeepers between competitions.
Wolves last played at Anfield in 2011, when Luis Suarez added to an own goal from Roger Johnson to seal a 2-1 win for the Reds, but Paul Lambert has steeled his side for a more hardened fight on Saturday.
However, with the quality at their disposal, Liverpool should be confident of rewriting their poor form and taking another step closer to the FA Cup final.
Liverpool: Karius; Randall, Gomez, Klavan, Moreno; Lucas, Wijnaldum, Ejaria; Firmino, Woodburn, Origi
Substitutes: Mignolet, Stewart, Milner, Can, Coutinho, Wilson, Sturridge
Wolves: Burgoyne; Coady, Hause, Stearman, Doherty; Edwards, Saville; Weimann, Evans, Costa; Dicko
Substitutes: Lonergan, Batth, Enobakhare, Ronan, Gibbs-White, Bodvarsson, Mason