Liverpool are still searching for their first FA Cup success since 2006, and a first trophy for five years.
The Reds welcome League 2 outfit Plymouth Argyle to Anfield on Sunday afternoon, with Jurgen Klopp fully expected to field a young team.
The Reds vs. the Pilgrims is one of 32 ties in the coming days – here’s a look at five others that stand-out.
Can Peterborough cause a huge upset at the Bridge?
The Blues’ attention now switches to FA Cup commitments, and although Peterborough United may be quaking in their boots a little, their opponents have shown they are not invincible.
The League 1 side having nothing to lose at Stamford Bridge – avoiding humiliation must be the order of the day – but a weakened Chelsea team is expected.
We have seen stranger things in football than Peterborough stunning the title favourites, like Bradford City’s 4-2 win there two years ago.
Pep out to avoid more criticism
After a perfect start to life in England, the wheels have come off slightly, and for the first time, he is being questioned a little.
City visit West Ham on Friday night in the first of the weekend action, and defeat to the Hammers would heap further pressure on the former Barcelona and Bayern Munich boss.
Unwanted 22nd birthday on the horizon for Everton
As Liverpool’s fans gleefully reminded them at last month’s Merseyside derby, it is now over 21 years without a trophy for Everton.
Paul Rideout’s winner in the 1995 FA Cup final feels like a lifetime ago now, and the longer the wait for silverware goes, the harder it gets.
A home loss would really make the home supporters disgruntled, and ensure that, come May, it will be 22 years without tasting success.
Arsenal after third FA Cup in four seasons
The trip to Championship side Preston North End could cause Arsene Wenger’s men an issue, with Simon Grayson’s side doing well this season and they almost caused upset against Man United last season.
An early goal for the hosts would test the mettle of a team famed for having a weak mentality.
Minnows out to spring a shock
This isn’t a round full of potential cup shocks, but three sides will be doing their best to be the talking point of the weekend.
Barrow, Eastleigh and Stourbridge are the lowest-placed teams remaining in the FA Cup, and their respective ties are not impossible to progress through.
Barrow and Eastleigh, both in the Conference Premier, host Rochdale and visit Brentford, respectively, with the former the more likely to cause an upset.
Meanwhile, Northern Premier League outfit Stourbridge take on League 2 Wycombe Wanderers at Adams Park – a side who had their own shock run back in 2000/01, when Liverpool beat them in the semi-finals.
Giant-killings remain few and far between these days, but when one happens, it can be one of the most glorious things to witness in football.
Fixtures & UK TV Info
Man United vs. Reading – 12:30pm, BT Sport 2
Accrington Stanley vs. Luton – 3pm
Barrow vs. Rochdale – 3pm
Birmingham vs. Newcastle – 3pm
Blackpool vs. Barnsley – 3pm
Bolton vs. Crystal Palace – 3pm
Brentford vs. Eastleigh – 3pm
Brighton vs. MK Dons – 3pm
Bristol City vs. Fleetwood – 3pm
Huddersfield vs. Port Vale – 3pm
Hull vs. Swansea – 3pm
Ipswich vs. Lincoln – 3pm
Millwall vs. Bournemouth – 3pm
QPR vs. Blackburn – 3pm
Rotherham vs. Oxford – 3pm
Stoke vs. Wolves – 3pm
Sutton vs. AFC Wimbledon – 3pm
Watford vs. Burton – 3pm
West Brom vs. Derby – 3pm
Wigan vs. Nottingham Forest – 3pm
Wycombe vs. Stourbridge – 3pm
Preston vs. Arsenal – 5:30pm, BT Sport 2
Cardiff vs. Fulham – 11:30am, BBC One Wales
Liverpool vs. Plymouth – 1:30pm, BT Sport 2
Chelsea vs. Peterborough – 3pm
Middlesbrough vs. Sheffield Wednesday – 3pm
Cambridge vs. Leeds – 7:45pm, BT Sport 2