The Reds take to St James’ Park for their final outing before the October international break, looking to build on their win away to Leicester City in the league last time out.
Held to a 1-1 draw at Spartak Moscow in midweek, however, Klopp’s side will be feeling the intensity of a gruelling night in the Champions League.
And the German has once again shuffled his pack, with Daniel Sturridge among those to come back into the side.
Liverpool have not taken on the Magpies since the end of the 2015/16 campaign, when goals from Papiss Cisse and Jack Colback cancelled out efforts from Sturridge and Adam Lallana.
This time out, Klopp will be eager for a better result than that 2-2 draw at Anfield.
For Newcastle, Rafa Benitez has named two ex-Reds in his starting lineup, with Javier Manquillo at right-back and Jonjo Shelvey in midfield.
Dwight Gayle, who often proved a scourge for Liverpool during his time at Crystal Palace, is on the substitutes’ bench.
Newcastle United: Elliot; Manquillo, Lascelles, Clark, Yedlin; Atsu, Merino, Shelvey, Ritchie; Perez, Joselu
Substitutes: Darlow, Gamez, Lejeune, Diame, Hayden, Murphy, Gayle
Liverpool: Mignolet; Gomez, Matip, Lovren, Moreno; Henderson, Wijnaldum, Coutinho; Salah, Sturridge, Mane
Substitutes: Karius, Klavan, Milner, Can, Oxlade-Chamberlain, Firmino, Solanke