The Reds have travelled to Andalusia for their fifth Group E outing, with victory at the Ramon Sanchez Pizjuan enough to secure progress to the last 16.
Jurgen Klopp‘s side drew 2-2 with Sevilla in their last meeting, but have since taken seven points from three games, including two victories over Maribor.
They are currently on a four-game winning streak, and Klopp will be eager to extend that to five as he utilises his squad for a vital European away clash.
Sevilla prepared for Tuesday’s clash with a 2-1 win over Celta Vigo in La Liga, with goals from Luis Muriel and Nolito sealing the three points.
They will provide the Reds with a major test of their credentials, but Klopp’s side can take confidence from their excellent form of late.
Sevilla: Rico; Mercado, Geis, Lenglet, Escudero; N’Zonzi, Pizarro; Sarabia, Banega, Nolito; Ben Yedder
Substitutes: Soria, Vazquez, Corchia, Krohn-Dehli, Navas, Correa, Muriel
Liverpool: Karius; Gomez, Lovren, Klavan, Moreno; Henderson, Wijnaldum, Coutinho; Salah, Mane, Firmino
Substitutes: Mignolet, Alexander-Arnold, Milner, Can, Oxlade-Chamberlain, Sturridge, Solanke