The Reds have made the long trip to East Sussex to take on Chris Hughton’s newly promoted Seagulls, looking to extend their unbeaten run to eight games.
Klopp has rotated his side in recent weeks, with five changes for the home draw with Chelsea and then six for the midweek victory away to Stoke.
And he has continued this approach at the Amex Stadium, for Liverpool’s first meeting with Brighton since 2012.
Gomez is absent due to illness, while Ragnar Klavan is available in reserve despite missing training on Friday.
Brighton: Ryan; Bruno, Duffy, Dunk, Bong; Knockaert, Propper, Stephens, Brown; Gross; Murray
Substitutes: Krul, Goldson, Schelotto, Kayal, Izquierdo, March, Hemed
Liverpool: Mignolet; Alexander-Arnold, Can, Lovren, Robertson; Henderson, Wijnaldum, Milner; Salah, Coutinho, Firmino
Substitutes: Karius, Klavan, Grujic, Oxlade-Chamberlain, Mane, Sturridge, Solanke