Press Association Sport looks at some of the biggest issues.
Debut For Van Dijk?
The clamour for the world’s most expensive defender to be parachuted into Liverpool’s team immediately has been growing since Virgil van Dijk completed his £75 million move to Anfield.
Klopp probably sees the visit of Manchester City next weekend as a more pertinent time to inject some much-needed defensive solidity into his side, as an outing against their closest rivals in the cut and thrust of a Friday night FA Cup after just three training sessions with his new team-mates may not be ideal.
With rumours of an imminent Barcelona bid for Philippe Coutinho there looks like being plenty of turmoil to come over the next month.
Coutinho and top scorer Mohamed Salah are both injured and will not play but the pair were also absent on New Year’s Day when a much-changed side came through a testing examination to beat Burnley at Turf Moor.
Coutinho chatter can wait until after the game.
At the time new manager Sam Allardyce was trying to stabilise a team trying to pull away from the relegation zone but he admits he can release the handbrake for a cup tie.
Allardyce has stated his desire to be more attacking than he was on his previous visit to Anfield.
But there is still likely to be a limit on how adventurous they will be for fear of getting taken apart by the Reds’ array of attacking talent.
Will Anfield Finally Witness a Winner?
A strange quirk of results means no one has ever scored a winning FA Cup goal in a Merseyside derby at Anfield.
In almost 118 years there have been four ties hosted at Liverpool’s ground and all have been drawn.
The first in 1902 finished 2-2, three years later it was 1-1, the 1991 tie was goalless and their most recent encounter in 2009 was another 1-1.