The Reds made a great start to their European campaign finishing top of Group E, three points ahead of both Sevilla and Spartak Moscow.
Undefeated in the group stage, Klopp’s side set up a knockout tie against Porto, with the first of two legs coming in Portugal.
Boosted by a comfortable 2-0 victory away to Southampton last time out, Liverpool can be hopeful of another vital win on the road, and Klopp has retained the majority of his starting selection from St Mary’s.
Loris Karius lines up in goal, with the German rapidly improving after being installed as Klopp’s No. 1.
Porto: Sa; Ricardo, Reyes, Marcano, Telles; Herrera, Oliveira, Otavio; Brahimi, Marega, Soares
Substitutes: Casillas, Pereira, Osorio, Oliver, Corona, Waris, Paciencia
Liverpool: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Henderson, Milner, Wijnaldum; Salah, Mane, Firmino
Substitutes: Mignolet, Matip, Gomez, Moreno, Oxlade-Chamberlain, Lallana, Ings