The wide forward netted the first, third and fifth goals on the night as the Reds ran riot in Portugal, taking a first-leg 5-0 victory back to Anfield.
Mane might have had a bit of fortune for the first, but his confidence and effectiveness on the ball soared thereafter and he was a constant threat for the Reds.
An outlet on the counter, hard-working defensively and ruthless with his finishing, Mane ended up with the match ball and the man of the match award.
Now the accolades could stack up further for his performance, with UEFA naming him as one of four candidates for their player of the week.
With Premier League sides putting up big performances all around there are plenty of familiar faces for Mane to try and see off.
Liverpool fans can choose for their preferred winner in the online poll by voting here.