The Reds look to get the job done in Italy after winning 5-2 in the first leg at Anfield last week, with avoiding complacency the key issue on Wednesday night.
Having been held to a 0-0 draw by Stoke City on Saturday, an injury-plagued squad headed to Rome seeking an immediate response.
Adam Lallana was also part of training at the stadium, but speaking at his pre-match press conference Klopp confirmed that the midfielder is “not really an option for the squad.”
Meanwhile Ben Woodburn will be hoping to make only his second appearance for the first team this season, after a lengthy spell out with illness.
Klopp’s starting lineup is likely to be very predictable, however, with few options to rotate in midfield and both defence and attack settled.
Liverpool Squad in Rome
Goalkeepers: Karius, Mignolet, Ward
Defenders: Van Dijk, Lovren, Klavan, Masterson, Alexander-Arnold, Clyne, Robertson, Moreno
Midfielders: Henderson, Wijnaldum, Milner, Lallana, Woodburn, Jones
Forwards: Firmino, Salah, Mane, Ings, Solanke, Camacho