Six wins in a row, and two games into their defining seven-game run, the Reds welcome their familiar adversaries to Anfield.
Jurgen Klopp could include three former Saints in his squad for Saturday’s clash, with three more on the treatment table, as they seek to maintain their perfect record.
But the Saints have won two and drawn one of their last three games, and will certainly present another tough test for the Reds.
After Tuesday night’s resounding victory over Paris Saint-Germain, however, Liverpool should be confident of taking another three points as their title challenge continues.
Check This Is Anfield for the latest team news ahead of the match.
You can also follow the game by downloading the This is Anfield app, including lineups, live coverage and all the reaction and analysis.
The match gets underway at 3pm (BST)—or 10am in New York, 7am in Los Angeles, midnight (Sunday) in Sydney, 6pm in Dubai and 5pm in Nairobi.
Liverpool vs. Southampton is not on TV for UK viewers, but This Is Anfield will have live updates of the clash throughout the afternoon.
Rest of the World
Supporters can find the Reds’ latest Anfield clash on the following channels worldwide:
beIN Sports HD 2, beIN SPORTS CONNECT, RMC Sport 1, SuperSport 3 Africa, SL2G, Flow Sports 1, Flow Sports App, DIRECTV Sports Argentina, DIRECTV Play Deportes, DIRECTV Sports Caribbean, Optus Sport, DAZN, Star Sports Select HD2, Kwese Live, Kwese Free Sports, Watch ESPN Brasil, ESPN Brasil, beIN Sports Connect Thailand, Astro Go, beIN Sports 2 Thailand, Diema Sport 2, Sportsnet Ontario, Sportsnet Pacific, Sportsnet Now, Sportsnet East, Sportsnet World Now, Sportsnet West, DIRECTV Sports Chile, BesTV, QQ Sports Live, PPTV Sport China, Ssports Live, DIRECTV Sports Colombia, Sky HD, SKY Planeta Futbol, Digi Sport 4, Viaplay Denmark, 6’eren, Eurosport Player Denmark, DIRECTV Sports Ecuador, Viaplay Finland, Viasat Football HD, Viasat Sports Premium, RMC Sport en direct, Cosmote Sport 1 HD, LeTV Sports Hong Kong, Stod 2 Sport, Star Sports Select 2, Hotstar, beIN Sports Connect Indonesia, beIN Sports 2 Indonesia, Sky Sport Football, SKY Go Italia, J Sports 4, SportsNavi Live, Astro Supersport, SPS HD, Ziggo Sport Select, Ziggo Sport 14, beIN SPORTS 1 New Zealand, beIN Sports Connect New Zealand, SuperSport 3 Nigeria, TV2 Sport Premium, TV2 Sumo, DIRECTV Sports Peru, beIN Sports Connect Philippines, beIN Sports 2 HD, Canal+ Sport Online, nc+ GO, Canal+ Sport 2 Poland, DIRECTV Sports Puerto Rico, Eurosport Romania, Match TV Game, NTV+ Sport Online, 102 (HD) mio Stadium, SuperSport CSN, Viaplay Sweden, PPTV HD 36, Digiturk Play, DIRECTV Sports Uruguay, DIRECTV Sports Venezuela
You can follow the action with us by downloading the This is Anfield app for free.