Chris Hughton’s Seagulls have been in decent form so far this season, sitting 13th in the table and on a run of four games without defeat, winning two of those.
But Liverpool are four points clear in first place and are yet to drop points to a side outside the top six, as well as winning in all three meetings with Brighton since they were promoted in 2017.
Required to navigate a host of injuries, Jurgen Klopp could again experiment with his lineup, but having made nine changes for the 2-1 defeat at Wolves on Monday night a stronger side can be expected in East Sussex.
Victory would put the Reds seven points clear of City, albeit temporarily, so Klopp will be eager for his side to keep the pressure up and respond with a win.
Check This Is Anfield for the latest team news ahead of the match.
You can also follow the game by downloading the This is Anfield app, including lineups, live coverage and all the reaction and analysis.
The match gets underway at 3pm (GMT)—or 10am in New York, 7am in Los Angeles, 2am (Sunday) in Sydney, 7pm in Dubai and 6pm in Nairobi.
Brighton vs. Liverpool is not on TV for UK viewers, but This Is Anfield will have live updates of the clash throughout the afternoon.
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Rest of the World
Supporters can find the Reds’ return to league action on the following channels worldwide:
beIN SPORTS CONNECT, beIN Sports HD 11, RMC Sport 1, SuperSport 3 Africa, SL2G, Flow Sports 1, Flow Sports App, ESPN2 Sur, ESPN Play Sur, Optus Sport, SBS, SBS Live, DAZN, Idman TV, Star Sports Select HD1, Play Sports 1, Canal+ Sport 2 Afrique, SportKlub 1 Serbia, Kwese Free Sports, Kwese Live, ESPN Brasil, Watch ESPN Brasil, beIN Sports 1 Thailand, Astro Go, Diema Sport 2, TSN4, TSN GO, RDS 2, RDS GO, BesTV, Guangdong Sports Channel, PPTV Sport China, QQ Sports Live, Ssports Live, ESPN2 Andina, Sky HD, Sportklub 1 Croatia, Cytavision Sports HD, Cytavision Sports 3, DIGI GO, Digi Sport 4, Viasat Ultra HD, TV3+ HD, Viaplay Denmark, Eurosport Player Denmark, TVPlay Sports, Sky Pacific, Viaplay Finland, Viasat Football HD, Viasat Sports Premium, RMC Sport en direct, Now E, Now Player, 621 Now Premier League 1, 620 Now Premier League TV, Spiler1, Stod 2 Sport, Star Sports Hindi 1, Hotstar, beIN Sports 1 Indonesia, beIN Sports Connect Indonesia, Sky Sports Premier League Ireland, SKY Go Italia, Sky Sport Uno, Sky Sport Football, SportsNavi Live, Setanta Sports Kazakhstan, SPOTV ON, Astro Supersport, GO TV Anywhere, TSN2 Malta, Blue To Go Video Everywhere, Skynet Sports 6, Ziggo Sport Select, Ziggo Sport 14, beIN Sports Connect New Zealand, SuperSport 3 Nigeria, TV2 Sumo, TV2 Sport Premium, Sport TV2, Eurosport Romania, Match TV Football 1, NTV+ Sport Online, 102 (HD) mio Stadium, SportKlub 1 Slovenia, SuperSport Maximo, #Vamos, Viaplay Sweden, Digiturk Play, S Sport+, S Sport, Futbol 2, OLL.tv, SCTV 17, Bongda TV
You can follow the action with us by downloading the This Is Anfield app for free.