It is another test of Liverpool’s credentials, with dropped points sure to build up the narrative that they are ‘bottling it’.
Away from the Reds’ trip to the Amex, there are nine other top-flight games to look forward to, with implications at both ends of the table.
Here’s a look at the upcoming action.
West Ham vs. Arsenal – Saturday, 12.30pm – Sky Sports Main Event
This looks like a possible cracker to open up the weekend proceedings.
The Hammers (10th) will believe seventh place is theirs for the taking this season, with just three points separating themselves and Leicester currently.
Arsenal, meanwhile, remain very much in the top-four battle, which could lead to an entertaining score draw.
Burnley vs. Fulham – Saturday, 3pm
Burnley have staged a mini-recovery after a desperate run of form, winning three games in a row in all competitions.
They are now out of the relegation zone and Sean Dyche will feel his team should get the better of 19th-placed Fulham on Saturday.
The Cottagers continue to struggle on their return to the top flight and they will be given an uncomfortable afternoon at Turf Moor.
Don’t expect a classic, but expect a Burnley victory.
Prediction: Burnley 1-0 Fulham
Cardiff vs. Huddersfield – Saturday, 3pm
Another relegation clash sees Cardiff host Huddersfield on Saturday afternoon, as Jurgen Klopp‘s great friend David Wagner desperately searches for three points.
The Terriers prop up the other 19 teams and if nothing changes quickly they will be doomed, with eight points separating them and the 17th-placed Bluebirds.
Cardiff are a grittier outfit and they look like they are going to do enough to retain their top-flight status for another year, as it stands.
A home win is likely, as Huddersfield fall further into the mire.
Prediction: Cardiff 2-1 Huddersfield
Crystal Palace vs. Watford – Saturday, 3pm
It may only be January, but this is set up as a meeting between two sides who will finish the season in mid-table.
Crystal Palace have threatened to get themselves into a relegation scrap, but they have too much quality to go down.
Watford, meanwhile, will be setting their sights on seventh, with Javi Gracia continuing to do an excellent job at Vicarage Road.
It’s a hard one to call, but Palace might just make the most of home advantage.
Leicester vs. Southampton – Saturday, 3pm
Leicester’s season is petering out a little, with their shock FA Cup defeat to Newport leaving them with only seventh place to play for in 2018/19.
The Foxes are a good side who will want to finish in the European places, however, as they fight off the chasing pack.
Claude Puel’s side are favourites to overcome Southampton this weekend, even though Saints are improving under new boss Ralph Hasenhuttl.
Leicester are generally good at home, despite losing to Cardiff last time around, and they should add three points to their tally.
Prediction: Leicester 2-0 Southampton
Chelsea vs. Newcastle – Saturday, 5.30pm – BT Sport 1
Chelsea have become a curious team, with their title challenge seeming a distant memory after a string of poor league results.
Fourth place is now the primary aim for Maurizio Sarri and his players, who have completely lost their early-season zip.
They shouldn’t have too much trouble overcoming Newcastle on Saturday evening, though, as Rafa Benitez attempts to defend his way to a positive result.
Chelsea will be too strong, but it won’t always be entirely convincing.
Prediction: Chelsea 2-0 Newcastle
Everton vs. Bournemouth – Sunday, 2.15pm – Sky Sports Main Event
Remember when Everton won the transfer window and were about to mount a top-four challenge? Heady days.
Liverpool’s Merseyside rivals have never been the same since Divock Origi‘s last-gasp winner at Anfield last month, winning just once in seven league outings.
They need to get back on track on Sunday, but Bournemouth will prove to be tricky opponents, even though their own season is in danger of falling apart a little.
A point apiece.
Tottenham vs. Man United – Sunday, 4.30pm – Sky Sports Main Event
In truth, United have had a lovely run of fixtures since Mourinho’s sacking and this is Solskjaer’s first genuine test.
Spurs find themselves back in the title race, so for once Liverpool supporters may actually be cheering on their old foes down the M62.
It is tough to see them getting anything, given their opponents’ superiority.
Man City vs. Wolves – Monday, 8pm – Sky Sports Main Event
The weekend action finishes on Monday night, in a match Reds fans are sure to be glued to.
City’s win over them on January 3 was a tough defeat to take, bringing the champions right back into the title reckoning.
Pep Guardiola’s men will be buzzing to showcase their brilliance once more when Wolves visit the Etihad, but the Premier League newcomers have caused big sides trouble all season.
In fact, Liverpool are the only ‘big six’ team they haven’t taken points off them, so they will believe they can cause another surprise.
If Conor Coady and his trusty deputies could do the Reds a favour, that would be much appreciated!
Prediction: Man City 3-1 Wolves