The Reds can go back to the top of the table with a point this afternoon, but will be desperate to take all three and do the double over United.
A brilliant 3-1 victory at Anfield back in December saw Klopp’s side embarrass their long-term rivals, but a change of manager in Manchester has seen today’s hosts revitalised.
Liverpool are boosted by the return of their defensive linchpin, and the hope will be that helps in their push for a 21st league win in 27 games this season.
Van Dijk missed Tuesday’s 0-0 draw with Bayern Munich through suspension, but though his stand-in performed excellently in the Champions League, his availability is paramount for the Reds.
Man United: De Gea; Young, Lindelof, Smalling, Shaw; McTominay, Herrera, Pogba; Mata, Rashford, Lukaku
Substitutes: Romero, Bailly, Dalot, Pereira, Fred, Lingard, Sanchez
Substitutes: Mignolet, Alexander-Arnold, Keita, Lallana, Shaqiri, Sturridge, Origi