The Reds head to Milton Keynes on the back of a tough week that saw them lose 2-0 at Napoli before a hard-fought 2-1 victory at Chelsea on Sunday.
Mane is not expected to be rule out for a lengthy period, but joining him on the absentee list for midweek is Shaqiri, who sustained a calf tear in training on Monday.
Speaking to LiverpoolFC.com before his press conference at Tuesday afternoon, Klopp’s assistant manager Pepijn Lijnders confirmed the Swiss would be unavailable.
“Yesterday towards the end of training, Shaq felt his calf stiffen up a little bit,” he explained.
“He couldn’t continue and a scan showed he had a little tear there.
“We need to wait a couple of days, but for sure he is not in contention for tomorrow. He needs some rest, so he will not be involved.”
Lijnders also ruled out Origi, saying the Belgian “has already been on the pitch, but not with the team yet so that’s his next step.”
Rhian Brewster is a shoo-in to debut up front, while Curtis Jones may be under contention, as could Harvey Elliott, who one year ago on September 25 became the League Cup‘s youngest-ever player while at Fulham.