The Reds produced a strong performance on their way to a 2-0 victory at Stamford Bridge at the weekend, before turning their focus to the cup.
Lincoln serve as tonight’s hosts, with Michael Appleton’s Imps enjoying a productive start to the season, currently sitting second in League One after two wins from two outings.
They will provide a much different challenge to Chelsea, and Klopp has tasked a much-changed side with stepping up to the plate.
Rhys Williams spent last season on loan with Kidderminster Harriers, and has been compared to Van Dijk in terms of style and looks.
This will be Grujic’s first appearance for Liverpool since December 2017, when he came off the bench in a 5-1 win at Brighton.
Fabinho, Harry Wilson and Diogo Jota are among the substitutes at Sincil Bank, with Liverpool hoping for a fluid display to push them to the fourth round of the League Cup for the second successive season.
Lincoln: Palmer; Bradley, Montsma, Eyoma, Melbourne; Edun, Bridcutt, Jones; Anderson, Grant, Scully
Substitutes: Ross, Jackson, McGrandles, Howarth, Roughan, Archibald, Hopper
Liverpool: Adrian; N.Williams, R.Williams, Van Dijk, Tsimikas; Grujic, Jones; Shaqiri, Minamino, Elliott; Origi
Substitutes: Kelleher, Van den Berg, Alexander-Arnold, Fabinho, Keita, Wilson, Jota