The Reds may head into the clash a few senior centre-backs light but they are aiming for four wins on the spin across all competitions.
Anfield will play host as the two teams battle for another three valuable points in what is the penultimate top-flight game ahead of yet another international break.
While Liverpool are starting to gain momentum after a disruptive few weeks, the Hammers similarly have the wind in their sails after a convincing win at Leicester, a comeback draw against Tottenham and a share of the spoils with Man City.
It sets up an intriguing battle as the Reds have been forced into yet another change in defence while West Ham will be without their in-form forward in Michail Antonio.
Liverpool have won six of the last eight meetings between the two sides, so will they make it seven from nine tonight and in-turn match the 63-game Anfield unbeaten run set by Bob Paisley’s men between 1978 and 1981?
Check This Is Anfield for the latest team news ahead of the match.
You can also follow the game by downloading the This is Anfield app, including lineups, live coverage and all the reaction and analysis.
The match gets underway at 5.30pm (GMT)—or 1.30pm in New York, 10.30am in Los Angeles, 4.30am (Sunday) in Sydney, 8.30pm in Dubai and 9.30pm in Nairobi.
Check our Rest of the World TV guide below for a list of TV broadcasters showing the match live.
Rest of the World
Supporters can find the Reds’ latest league clash on the following channels worldwide:
SuperSport 3 Digitalb, beIN Sports HD 2, beIN Sports HD 1, beIN SPORTS CONNECT, RMC Sport 1, SuperSport Maximo, SuperSport Premier League ROA, DStv Now, Flow Sports App, Flowsports.co, ESPN Play Sur, ESPN Sur, RUSH, Optus Sport, Sky Go, Sky Sport 1/HD, Idman TV, Star Sports Select HD2, Belarus 5, Play Sports 1, VOOsport World 1, Watch ESPN Brasil, ESPN Brasil, Astro Go, Play Diema Xtra, Diema Sport 2, DAZN, QQ Sports Live, Sky HD, Premier Sport, DIGI GO, Cytavision on the Go, Cytavision Sports 3, Viaplay Denmark, TV3+ HD, ESPN Andina, TV3 Sport, Viaplay Finland, V Sport Jalkapallo, V Sport Premium, Canal+ Sport 3 Afrique, Canal+ France, RMC Sport en direct, Free, Sky Ticket, Cosmote Sport 1 HD, Now Player, 620 Now Premier League TV, 621 Now Premier League 1, Spíler1, SíminnSport, Hotstar VIP, Star Sports Select 2, Mola TV App, mola.tv, Sport 1, SKY Go Italia, Sky Sport Football, NOW TV, Setanta Sports Kazakhstan, SPOTV ON, Astro SuperSport 3, TSN2 Malta, GO TV Anywhere, Blue To Go Video Everywhere, Skynet Myanmar, Ziggo Sport Select, Ziggo Sport 14, Spark Sport, SuperSport Premier League Nigeria, TV2 Sport Premium, TV2 Sumo, Premier FOOTBALL, Canal+ Sport Online, Canal+ Sport, Canal+ 4K Ultra HD, nc+ GO, Sport TV2, Sport TV LIVE, Eurosport Romania, Eurosport Player Romania, Okko Sport, mio Stadium 108, 102 (HD) mio Stadium, V Sport Extra, Viaplay Sweden, S Sport+, S Sport, Setanta Sports Ukraine, SiriusXM FC, UNIVERSO NOW, Telemundo Deportes En Vivo, UNIVERSO, K+PM
You can follow all the action tonight and throughout 2020/21 with us by downloading the This is Anfield app for iPhone and Android for free.