Mane has netted each of the last three goals scored at Anfield in this fixture.
But his last league goal came in the Merseyside derby at Goodison.
Meanwhile, Salah has not scored in his last three appearances in league and cup after netting each of his previous four. He has eight goals in nine top-flight games.
Despite those issues at centre-back, Liverpool have conceded just six goals in their last 10 games in all competitions, keeping five clean sheets in that period.
Goal-shy at Anfield
Wolves have scored just four times in their last 15 league visits to Anfield – a run dating back to 1972 – while in that time they have kept two clean sheets, winning both matches 1-0 when they were bottom of the league in January 1984 and again in December 2010.
They have not scored more than once in a league game at Anfield since Steve Kindon and John Richards netted in a 4-2 defeat in September 1972.
Home and away they have scored more than once against Liverpool in one of the last 30 top-flight meetings. That helped them to a 4-1 home win in 1980.
First goal wins?
They have scored in the first half of 26 of their last 86 Premier League games.
Ex-Reds and a bitter reunion
It brought to an end a sequence of 119 successive league appearances.
Nelson Semedo came on as a 60th-minute substitute for Barcelona on that memorable Anfield evening in May 2019.
He sent off Willy Boly in a defeat at Man City in January 2019.
This season’s scorers
Liverpool: Salah 10, Jota 9, Mane 5, Jones 3, Minamino 3, Firmino 2, own goals 2, Grujic 1, Origi 1, Robertson 1, Shaqiri 1, Van Dijk 1
Wolves: Jimenez 4, Neto 3, Podence 2, Ait-Nouri 1, Saiss 1
* Statistics courtesy of LFC statistician Ged Rea (@ged0407).