It will see Jannik Vestergaard free to play after the red card he received against Leicester was rescinded following an appeal and review by an independent regulatory commission at the FA.
The centre-back was handed his marching orders inside 10 minutes in their 1-1 draw on Friday after being deemed to have impeded Jamie Vardy with his trailing foot in a highly controversial decision.
As much you would like to have, the defeat to Southampton at the turn of the year is one that is hard to forget as it kickstarted a tumultuous run of form.
It has seen Southampton drift closer to the red zone while the Reds continue to battle for a European spot having amassed 21 points in the same time period.
Southampton have had to deal with a long list of injuries, one which is to see them without Ings, Oriol Romeu, Ryan Bertrand and Will Smallbone on Saturday evening.
But Jurgen Klopp and co. can expect Fraser Forster to start in goal ahead of Alex McCarthy after Hasenhuttl revealed he is rotating his goalkeepers every two games.