Here are 10 things to know ahead of the match.
1. Chelsea suffer shock dip
Their form has completely deserted them, however, with a mixture of poor performances, injuries and Covid holding them back.
The midweek draw with Brighton was the latest setback and Thomas Tuchel’s side have now only won two of their last six league games.
They are eight points adrift of Man City without the game in hand Liverpool hold, and losing more ground on them this weekend would surely spell the end of their title challenge.
2. Potential Blues lineup
As mentioned, Chelsea have lost a number of key figures to injury and illness, meaning they will be short on Sunday.
Ben Chilwell is expected to miss the rest of the season with a knee injury, but the England international’s absence only scratches the surface.
Reece James is out with a torn hamstring, while the same could apply to Andreas Christensen after both limped off against Brighton.
Thiago Silva, Timo Werner and Ruben Loftus-Cheek are all doubts, too.
Romelu Lukaku should lead the line, meaning a physical battle with Virgil van Dijk will take place.
Possible Chelsea XI: Mendy; Sarr, Chalobah, Rudiger; Azpilicueta, Kante, Jorginho, Alonso; Mount, Havertz, Lukaku
3. Who’s missing for Liverpool?
Meanwhile, three fresh positive Covid cases have further rocked Liverpool’s preparations ahead of the game – the unnamed trio are out of the game unless they return a negative PCR test.
Meanwhile, Andy Robertson is still suspended.
4. Predicted Liverpool XI
Given the must-win nature of Sunday’s trip to west London, it would be a shock if Liverpool’s strongest possible XI didn’t take to the field.
Sadio Mane is also badly out of form and Klopp may consider bringing in Firmino, if he is available. The Senegalese is still likely to start, though.
Predicted Liverpool XI: Kelleher; Alexander-Arnold, Matip, Van Dijk, Tsimikas; Fabinho, Henderson, Keita; Salah, Mane, Jota
5. Stamford Bridge improvements
There was a time when Liverpool seemed incapable of beating Chelsea away from home, only winning once at Stamford Bridge between 1989 and 2008.
That came in January 2004, thanks to a Bruno Cheyrou strike.
In the Klopp era, however, the Reds have fared much better, only suffering defeat there on one occasion in the league, back in May 2018.
Liverpool picked up a 2-0 win in west London last season, thanks to a Mane double, as well as a 2-1 triumph in the title-winning campaign.
A third successive victory at Chelsea this weekend is paramount.
6. Worrying Thiago update
Speaking to the media on Friday, Klopp admitted that Thiago‘s injury is a complex one, leading to fears that he could be out for an extended period:
“Taki is probably closer. Taki is running outside, Thiago not yet. It means for him it might take a bit longer.
“It’s a hip issue, which we actually have no idea where it’s coming from, so we have to be a little bit patient with that.”
Having won all nine games he has started this season, it really is vital that Liverpool get the Spaniard back on the pitch as soon as possible.
7. Lukaku’s criticism of Tuchel
They have a history of managers falling out with players and it appears as though the same could be about to happen.
Speaking earlier in the week, Lukaku hinted that he was unhappy at Chelsea currently, threatening to spark a fallout with Tuchel:
“I think the coach has chosen to play with another system, I just have to not give up and continue to work and be a professional.
“I am not happy with the situation, but I am a professional and I won’t give up.”
8. Did you know?
Mane is experiencing a tough time of things, as doubts continue to linger regarding whether or not he has peaked as a player.
The Senegalese has now failed to register a single goal or assist in his last nine appearances, stretching back to the 4-0 win at home to Arsenal on November 20.
While Mane is still better than most wide players in the league, there is a feeling that he is dipped below the world-class level he has reached in the past.
One big performance before departing for the Africa Cup of Nations would be ideal.
9. Worrying referee appointments
Manchester-born Anthony Taylor will take charge of the weekend action, which is unlikely to go down well with many Liverpool fans.
Not only that, but Paul Tierney is on VAR duty, fresh off the back of his appalling showing away to Spurs when he somehow failed to show Harry Kane a red card.
Buckle up folks, this one could be frustrating!
10. “And it’s live”…
Sunday’s match is live on Sky Sports Main Event from 4.15pm (GMT), with kickoff at 4.30pm.
Our matchday live blog will also be available from 3.45pm, as Henry Jackson guides you through all the action from Stamford Bridge.
Come on you Reds.