Though City pulled further ahead in the title race with a 1-0 win over Chelsea on Saturday, a win for Liverpool would at least see them jump two points ahead of the Blues in second, with a game still in hand.
Here are 10 key things to know ahead of the game.
1. Brentford enjoying solid Premier League season
The Bees secured promotion to the Premier League last May, and while many tipped them to swiftly return to the Championship, they have been a breath of fresh air.
With just over half the season gone, Thomas Frank’s side sit 13th in the table and a distance clear of the relegation zone, suggesting safety is on the cards.
That being said, Brentford will know that long, winless runs are possible in the top-flight and they still have work to do to get to that magical 40-point mark.
The 3-3 draw at home to Liverpool last September showed what the west Londoners are capable of, however, and they will pose a threat this weekend.
2. Possible Bees starting XI
The Bees have injury problems, though, with David Raya, Mathias Jorgensen, Charlie Goode and Josh Dasilva all missing out this weekend. Frank Onyeka is on Africa Cup of Nations duty with Nigeria.
Left-back Rico Henry may return, having not featured since December 22 against Chelsea, and former Liverpool man Sergi Canos could start, too.
Ivan Toney gave Liverpool’s defence a torrid time in the reverse fixture and he is expected to lead the line, along with Bryan Mbeumo.
Predicted Brentford XI (3-5-2): Lossl; Ajer, Jansson, Pinnock; Bidstrup, Janelt, Norgaard, Baptiste, Canos; Mbeumo, Toney
3. Who’s out for Liverpool?
Liverpool’s COVID issues have now eased, thankfully, with no new positive cases emerging since the Arsenal game.
Klopp has confirmed that there are no new injuries to worry about after the midweek action.
4. Predicted Reds’ starting lineup
The pair look highly likely to start on Sunday, meaning Jota could adopt more of a wide role to accommodate Firmino centrally.
5. Klopp reaches latest milestone
Sunday will see Klopp take charge of his 350th game as Liverpool manager – where on earth does the time go?
Klopp’s contract expires in 2024, however, and there is a nagging feeling that we are closer to the end of his reign than the beginning.
The hope is that one day we are celebrating the German’s 700th match in charge – that could be wishful thinking on our part, though!
6. Boss wary of Brentford threat
Speaking in his pre-match press conference on Friday, Klopp was under no illusions about the task awaiting his side:
“I expect a fight. They have a specific way to play, especially against us. We have to be alert, ready. They will probably be direct.
“They are playing a brilliant first season in the Premier League, absolutely impressive. I hope we can play much better than in the first game, and use Anfield.”
While Brentford are a talented team in their own right, there is no denying that anything other than a Reds victory would feel disastrous.
7. Liverpool’s record vs. Brentford
This weekend will see Liverpool and Brentford face each other for the 17th time in history – it’s fair to say the Reds have enjoyed the fixture over the years.
The Bees have only tasted success over the Merseysiders three times, with all of those victories coming way back in the 1930s (1936, 1937 and 1938).
The most recent meeting between the two clubs before this season’s clash was an FA Cup quarter-final tie at Anfield back in March 1989.
Sir Kenny Dalglish’s side ran out 4-0 winners that day, thanks to Peter Beardsley’s brace and further goals from John Barnes and Steve McMahon, as Liverpool went on to win the competition after a final win over Everton.
8. Did you know?
Firmino should lead the line on Sunday and in the coming weeks, with end product required in the absence of Salah and Mane.
The Brazilian hasn’t necessarily been renowned for his ruthlessness in the final third, but his record this season suggests otherwise.
Firmino has averaged a goal or an assist every 78 minutes in 2021/22, with seven of the former and three of the latter to his name.
In comparison, the 30-year-old’s average last season was 187 and 157 in the title-winning year, while his best tally for an entire campaign is 95 minutes in 2017/18.
9. Moss takes charge
Jon Moss has been confirmed as the referee for Sunday’s clash, while Lee Mason will be on VAR duty.
This is the second Liverpool game that Moss has officiated this season, with the 51-year-old overseeing the 5-0 win away to Watford in October.
He has shown four red cards in the league this season to date, with all of them the result of two yellows.
10. Follow our live blog
Sunday’s match is not live on UK television, which means TIA’s matchday live blog is the place to follow the action.
Joanna Durkan will be in the hotseat from 1.15pm (GMT) – kickoff is at 2pm – as she provides intriguing pre-match content and minute-by-minute updates.