The Reds head into today’s tie 13 points behind their long-time rivals in the Premier League, having only won two of their eight games so far.
But a 7-1 thrashing of Rangers in midweek served as a major boost to confidence on Merseyside, which they will need as they take on the free-scoring champions.
Klopp is once again bound by fitness issues throughout his squad as he names his side to face City, with Alisson among those able to keep his place.
Beyond the back four, it is unclear yet whether it will be a 4-4-2 or 4-3-3.
Substitutes: Kelleher, Phillips, Alexander-Arnold, Tsimikas, Henderson, Bajcetic, Jones, Carvalho, Nunez
Man City: Ederson; Akanji, Dias, Ake, Cancelo; Rodri, De Bruyne, Gundogan; Silva, Foden, Haaland
Substitutes: Ortega, Laporte, Gomez, Wilson-Esbrand, Lewis, Palmer, Mahrez, Grealish, Alvarez