Currently sitting in the relegation zone with five points from 10 games, it serves to be a mismatched clash for the Hatters.
It will be Madley’s 11th time in charge of a Liverpool game, with the Reds not suffering defeat in any of the previous 10 and winning seven of those.
His last outing as referee for Liverpool was their 7-0 thrashing of Man United in March, which went largely without event from his perspective.
In fact, Madley has never sent a player off in any Liverpool fixture and has only awarded one penalty in those 10 games.
That was during the 2-2 draw with Fulham at the start of last season, with the Cottagers given a spot-kick despite Aleksandar Mitrovic clearly diving in the box.
VAR for Sunday will be Craig Pawson, and fourth official Anthony Taylor, with Harry Lennard and Nick Hopton serving as assistant referees.
Madley was VAR for Liverpool’s last league game, the 3-0 victory over Nottingham Forest, and again there were few flashpoints for the 40-year-old to consider.
He has refereed five Luton fixtures in the past, with their record standing at two wins, a draw and two losses – the most recent being a 1-0 victory over Rotherham in 2020.