The Gunners were already set to be without the injured trio of Jurrien Timber, Thomas Partey and Fabio Vieira for today’s clash, plus Takehiro Tomiyasu and Mohamed Elneny due to international duty.
Jesus will be absent for the 4.30pm kickoff with a knee problem, which is likely to see Eddie Nketiah start in his place.
Nketiah has scored six goals and laid on four assists in 26 appearances so far this season, having often been required to fill in for Jesus, who himself has scored seven and assisted three in 21 games.
Aaron Ramsdale is expected to take over from David Raya in goal, while the left-back spot hinges on whether or not Oleksandr Zinchenko is passed fit.
Jorginho, Emile Smith Rowe, Leandro Trossard and Reiss Nelson are other options to be brought in, but unlike Liverpool, Arsenal have an extended break after this fixture.
A draw in today’s clash would, however, set up a replay which is due to be held in the week commencing January 15.
Possible Arsenal XI vs. Liverpool: Ramsdale; White, Saliba, Gabriel, Zinchenko; Rice, Odegaard, Smith Rowe; Saka, Trossard, Nketiah