Klopp has made changes to his starting XI for the last two games, following two changes against Newcastle with the same number in Naples.
The German is sure to switch things up again as the Reds look to bounce back from a draining night in Napoli with a return to winning ways at Stamford Bridge.
The big question is whether more alterations will be made against Frank Lampard’s side, with this the third big game of a testing week.
Here’s how Liverpool’s starting lineup could look at Stamford Bridge.
Injury Update & The Squad Available
Klopp gave a positive injury update in his pre-match press conference, but not one that changes the picture drastically ahead of Sunday’s showdown.
The best news came with Klopp confirming Naby Keita joined team training on Friday, but Sunday will almost certainly come too early for the No.8 to feature.
Meanwhile, it appears Andy Robertson suffered no ill effects after passing a late fitness test to play against Napoli, ensuring the left-back should be fit to play.
It all means the same squad is available as against Napoli, and changes could be made with strong options in all departments.
With striking options in short supply, Rhian Brewster could come into the matchday fold against his former club.
Liverpool’s Possible Lineup vs. Chelsea
This may well be the third game of a tough week for Liverpool, but there is no doubt Klopp will go with his strongest team.
The Reds have enjoyed a healthy gap between games and have the chance to conduct full rotation in Wednesday’s League Cup tie at League One side MK Dons.
Klopp will, therefore, go with his strongest XI at Stamford Bridge, keeping changes to a minimum and adding only some fresh legs where needed.
The midfield is always the area Klopp freshens up first, and that should be the case again as the back-four and attack very much pick itself at this stage.
It could be that we just see the one change made, with Wijnaldum coming in to replace Milner to give the Reds the familiar big-game XI.
On the other hand, Klopp could opt for a few further changes to inject some greater freshness after a taxing night in the Naples heat for his players.
One of those could see a rare defensive switch made in Gomez replacing Alexander-Arnold for a little more defensive security in a top-six clash away from home.
Another pair of fresh legs could be added to midfield along with Wijnaldum to ensure the Reds have the energy for a full-throttle performance.
This, hopefully, would see Oxlade-Chamberlain restored to provide some attacking thrust in support of the traditional front three.
It seems more likely that Klopp will opt for something closer to the first selection, starting with a more solid than adventurous team for a top-six clash away from Anfield.
This is a very winnable game for the Reds though, which could tempt the boss into naming the more attacking XI in an attempt to pick up a huge three points.